男性不妊の研究 第2編: 睾丸における抗原抗体反応に関する研究:活動性アナフィラキシー時および逆アナフィラキシー時の睾丸の組織学的変化

Abstract

The rabbit testes were exposed to the active anaphylaxis with the bovine erythrocyte as antigen and the reverse anaphylaxis with the anti-rabbit erythrocyte sera of the guinea pig. Allergic orchitis ensued, the main findings of which were vascular and hemorrhagic changes. Spermatogenesis was markedly damaged, and there were degeneration of germ cells and appearance of giant cells. The follow-up study showed that changes in the seminiferous tubuli were still progressive without regeneration even at the time when the stroma was already toward regeneration. From the experimental results and the study of Part 1, the relation between mumps orchitis and spermatogenic failure was discussed.