尿路感染症に対するCephalexin-Lillyの使用経験

Abstract

Cephalexin was administered to the patients with urinary tract infection and the following results were obtained. 1. Very good results were obtained in non-complicated urinary tract infections. There was no difference between the group of 1 gram per day and that of 2 grams. 2. For complicated urinary tract infections, two grams were administered. Effectiveness in percentage was 72.2. 3. Effectiveness against urinary bacteria was studied. Seventy-five per cent of Staphylococcus; fifty per cent of E. coli and forty per cent of Klebsiella infections showed disappearance of microorganism from urine. No effectiveness was observed in Proteus and Pseudomonas infections. 4. MIC for clinically isolated strains was fairly well correlated with clinical or bacteriologic effects. 5. When 500 mg of cephalexin was orally administered, the blood level reached the peak of 15.8 pg/ml in one hour and• was quickly lowered reaching the immeasurably low level in seven hours. 6. As to side effect, two cases of slight gastrointestinal disorder were noted. 7. No ill effects on liver or kidney functions were observed at all.