尿路結石症に対するSPANATE(flopropione)の治験 雄犬の尿管収縮運動および血圧におよぼす影響

Abstract

Thirty-one cases of urolithiasis were treated with the administration of SPANATE (fiopropione) and seventeen cases were successfully treated (60.7 %). Ninety-three per cent of the stone passed were within 7×8 mm in size and their average duration to be passed to the bladder required 16.2 days. Ureteral peristalsis and blood pressure after intravenous injection of fiopropione were observed by means of electromanometer with strain gauge in six dogs. When the dose was greater than 10 mg/kg, peristaltic tonus was weakened and peristaltic frequency was increased. The blood pressure remained unchanged except a slight decrease immediately after the injection of fiopropione of the dose over 10 mg/kg.