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タイトル: | Pivmecillinam(PMPC)の前立腺肥大症術後管理療法に対する臨床評価 |
その他のタイトル: | Prophylactic and chemotherapeutic efficacy of pivmecillinam (PMPC) against infections after TUR-P and prostatectomy |
著者: | 丸, 彰夫 三橋, 公美 斯波, 光生 大橋, 伸生 藤枝, 順一郎 西田, 亨 大越, 隆一 草階, 佑幸 網野, 勇 兼田, 達夫 川倉, 宏一 阿部, 弥理 波治, 武美 有門, 克久 大塚, 晃 南, 茂正 |
著者名の別形: | Maru, Akio Mitsuhashi, Kimiyoshi Shiba, Teruo Ohashi, Nobuo Fujieda, Junichiro Nishida, Tohru Okoshi, Ryuichi Kusakai, Yuko Amino, Isamu Kaneda, Tatsuo Kawakura, Koichi Abe, Nobumichi Namiji, Takemi Arikado, Katsuhisa Otsuka, Akira Minami, Shigemasa |
キーワード: | Age Factors Amdinocillin Pivoxil/adverse effects/therapeutic use Drug Evaluation Humans Male Penicillanic Acid/therapeutic use Postoperative Care Postoperative Complications Premedication Prostatectomy Prostatic Hyperplasia/surgery Pyuria/drug therapy Urinary Tract Infections/drug therapy/prevention & control |
発行日: | Feb-1983 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 29 |
号: | 2 |
開始ページ: | 245 |
終了ページ: | 253 |
抄録: | The prophylactic and chemotherapeutic efficacy of PMPC against infections after TUR-P has been investigated. Bacteriological evaluation: PMPC , 200-300 mg/day for 2-12 weeks, was administered to 49 patients, who had over 10(3)CFU/ml of microorganisms after CET or CEC treatment for 3-7 days. The eradication rate of microorganisms was 40.8% after 2 weeks, 52.2% after 4 weeks, 64.1% after 6 weeks, 65.0% after 8 weeks and 70.6% after 12 weeks. Effectiveness on pyuria : The improvement rate of pyuria against 59 patients who had over 10(5)/hpf of pyuria , was 15.3% after 2 weeks, 16.4% after 4 weeks, 25.4% after 6 weeks, 58.5% after 8 weeks, 72.7% after 10 weeks and 75.0% after 12 weeks. Overall clinical efficacy on PMPC was examined in 26 patients. The results of efficacy were 27.3% after 2 weeks, 48.0% after 4 weeks, 50.0% after 6 weeks, 69.2% after 8 weeks, 75.0% after 10 weeks and 77.0% after 12 weeks. The clinical response was evaluated according to a criterion for clinical evaluation of antimicrobial agent on chronic complicated UTI proposed by UTI committee in Japan. No severe adverse effect including allergic reaction was found. Following administration of PMPC , three patients experienced adverse gastric reactions, and drug administration was discontinued at week 6 or 8. PMPC was effective as a prophylactic chemotherapeutic drug against infections after TUR-P and prostatectomy. |
URI: | http://hdl.handle.net/2433/120112 |
PubMed ID: | 6203380 |
出現コレクション: | Vol.29 No.2 |
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