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Title: ウレアーゼ阻害剤による尿路結石の予防 第4報 : 新ヒドロキサム酸と抗生剤セファレキシンとの併用によるラット感染結石の治療
Other Titles: Prevention of infected urinary stones by urease inhibitor. IV. Treatment of infection stones in rats by a new hydroxamic acid and cefalexin
Authors: 竹内, 秀雄  KAKEN_name
友吉, 唯夫  KAKEN_name
岡田, 裕作  KAKEN_name
吉田, 修  KAKEN_name
小橋, 恭一  KAKEN_name
Author's alias: Takeuchi, Hideo
Tomoyoshi, Tadao
Okada, Yusaku
Yoshida, Osamu
Kobashi, Kyoichi
Keywords: Animals
Cephalexin/therapeutic use
Disease Models, Animal
Drug Therapy, Combination
Hydroxamic Acids/therapeutic use
Male
Proteus Infections/complications/drug therapy
Proteus mirabilis
Rats
Urease/antagonists & inhibitors
Urinary Bladder Calculi/drug therapy/etiology/prevention & control
Urinary Tract Infections/complications/drug therapy
Issue Date: Mar-1983
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 29
Issue: 3
Start page: 297
End page: 302
Abstract: ラット感染結石に対しウレアーゼ阻害剤N-ピバロイルグリシノヒドロキサム酸(P-GHA)を抗生剤セファレキシン(CEX)との併用にて治療効果を検討した.(1) P-GHAはCEXとの併用によって,それぞれ単独では効果のない投与量でも結石増大抑制効果がみられ,投与量を増やした場合には結石溶解もみられた.(2) CEXの大量投与により感染の抑制および結石溶解効果がみられた.(3) MAP結石は感染尿が正常化されれば溶解しうる.(4) P-GHAあるいはほかの強力なウレアーゼ阻害剤は適当な抗生剤との併用により結石増大抑制だけでなく,結石の溶解および尿路感染の治癒の可能性が示唆された
We investigated the combined effectiveness of a new urease inhibitor, N-( pivaroyl ) glycinohydroxamic acid, with Cefalexin in the treatment of infection stones in rats. Combination therapy with the hydroxamic acid and Cefalexin inhibited bladder stone formation, and dissolved the stone dose dependently, while separate therapy was not significantly effective against stone formation or bacterial growth. This compound may become a useful medicine for the treatment of infection stones.
URI: http://hdl.handle.net/2433/120139
PubMed ID: 6375315
Appears in Collections:Vol.29 No.3

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