尿路Serratia感染症の統計的観察

Abstract

1)1975年から7年間に泌尿器科入院患者1, 773名中327名の尿よりSerratiaを分離した.2)過去7年間の入院と外来患者の尿より分離した細菌の年度別頻度は常にSerratiaが第1位を占めた.3) Serratiaを分離した例はすべてなんらかの基礎疾患を有し, 高齢者が多く, 大部分手術後に分離し, 感染防禦機能の低下した状態で出現した.4) Serratia発生に留置カテーテルが関与したと思われる例は327例中276例で, nosocomial infectionを示唆した.5)感受性はCPが86.1%ともっとも高く, ついでAMK 70.0%, ST 36.4%, FOM 31.3%であった.GM, DKB, KMは感受性が低かった

Recently, in many institutions, Serratia marcescens has been isolated more frequently. Therefore, we made a statistical analysis of S. marcescens infections. S. marcescens was isolated from the urine of 327 of the 1, 773 patients admitted to our Department between 1975 and 1981. S. marcescens was the most frequently isolated organism in the urine of both inpatients and outpatients all of the 7 years. S. marcescens was often isolated in patients with some underlying disease, elderly patients or postoperative patients, in which case the individual defense mechanism protecting the patient from infections is often low. Because 276 of the patients who had S. marcescens infection had urethral indwelling catheters, S. marcescens infection may be nosocomial. The most effective antibiotic against S. marcescens was chloramphenicol followed by amikacin, sulfamethoxazole-trimethoprim, and fosfomycin. The effectiveness of gentamycin, dibekacin and kanamycin was not as high as expected.