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Title: Establishment of a cell line (TSUS-1) derived from a human squamous cell carcinoma of the penis
Other Titles: ヒト陰茎扁平上皮癌培養細胞株TSUS-1の樹立とその性状
Authors: Ishikawa, Satoru
Kanoh, Shohri
Nemoto, Shinichi
Author's alias: 石川, 悟
加納, 勝利
根本, 真一
Keywords: Adult
Carcinoma, Squamous Cell/genetics/pathology
Cell Line
Genetic Markers
Mice, Inbred BALB C
Penile Neoplasms/genetics/pathology
Issue Date: Apr-1983
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 29
Issue: 4
Start page: 373
End page: 376
Abstract: 37歳男性の電撃型陰茎癌患者の転移を認めた心嚢液よりヒト陰茎扁平上皮癌培養細胞株TSUS-1を樹立した.継代培養は60代におよび2年5ヵ月を経過した現在なお増殖を続けており,ヌードマウス皮下移植率は100%であった.継代培養40代の染色体分析でモード75の低四倍体で,マーカー染色体を7個認めた.ヌードマウス移植腫瘍は皮膚に浸潤し,角化傾向も著明で,原発巣の陰茎癌類似の肉眼的所見を示し,組織学的には癌真珠を含む角化傾向を散見する扁平上皮癌で,原発陰茎癌に類似していた
We established a cell line ( TSUS -1) derived from a relatively well-differentiated squamous cell carcinoma of the penis. The cells had been subcultured 60 times during two years and five months. The average doubling time of this cell line was 38 hours. Chromosomal analysis indicated that the modal chromosome number was 75; seven marker chromosomes and a male karyotype were present. The cultured cells were easily transplantable into BALB/c nude mice and the histological picture of the inoculated tumor was similar to that of the original tumor.
PubMed ID: 6587762
Appears in Collections:Vol.29 No.4

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