前立腺肥大症の保存的療法 --オキセンドロンの臨床的検討と尿流量測定・超音波断層法による評価--

Abstract

前立腺肥大症65症例でオキセンドロン(Prostetin(R)) 200 mg/週を12回投与した.自覚症状の改善は58.5%にみられ, 他覚所見の改善は35.0%にみられた.触診・尿流量測定, 経直腸的超音波断層法による検討を含め自・他覚所見の推移に相関はみられず, 本剤の前立腺腫縮小効果も明確にしえなかった

65 patients with BPH were treated with 200 mg oxendolone (Prostetin®) given intramuscularly at the dose of 200 mg a week for 12 weeks. Subjective symptoms were improved in 58.8 % of these patients. Objective improvement was estimated by rectal palpation, uroflowme try, residual urine volume measurement, urethrocystography, transrectal ultrasonography and endoscopy. Improvement of objective findings were observed to some extent in 35.0% of the patients. But in almost all the patients no evaluable changes were noticed by uroflowmetry or ultrasonography. The changes in the subjective symptoms and objective findings in each case were compared, and a remarkable discrepancy was noticed between the two categories. It is suggested that the subjective improvement in these patients is not based on reduction of prostatic size.