膀胱癌患者の細胞性免疫能に関する研究 第9報 : 末梢血リンパ球のspecific S.I.について

Abstract

1)膀胱癌患者28例, 対照群10例について膀胱癌組織3MKCl抽出液を抗原としたspecific S.I.を検討した.2) low stage群の反応性がもっとも高く, ついでlow grade群が高値を示し, high stage群はもっとも低値であった.3)術後のspecific S.I.の変動をみると根治的手術例では術後1ヵ月頃より反応性は低下しはじめ, 6ヵ月頃より消失する傾向にあったが, 根治的手術不能例では逆に3-6ヵ月後より上昇する傾向が認められた.4)本方法はその手技が安易であり, 抗原作製法の改善が得られれば臨床的に応用することが可能と考えられる

Soluble extracts were obtained from bladder carcinoma tissue treated with a 3M KCI solution and prepared as a tumor associated antigen for the study of specific S.L Twenty eight bladder carcinoma patients and 10 control subjects were selected for the study. The response was the strongest in the low stage group followed by the low grade group. The high stage group gave the lowest response. The change in specific S.I. suggested that the response starts to decrease one month after surgery in the cases of radical surgery and tends to disappear approximately after 6 months. But, in the cases where radical surgery could not be performed, the response tended to increase from 3 to 6 months after surgery. Since this method does not require high skill, it may be clinically valuable after improvement of the antigen preparation method.