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タイトル: Sipple症候群の2例
その他のタイトル: SIPPLE'S SYNDROME : REPORT OF TWO CASES
著者: 安川, 修  KAKEN_name
中村, 順  KAKEN_name
新家, 俊明  KAKEN_name
小川, 隆敏  KAKEN_name
森, 勝志  KAKEN_name
大川, 順正  KAKEN_name
吉田, 利彦  KAKEN_name
曽根, 正典  KAKEN_name
三軒, 久義  KAKEN_name
著者名の別形: Yasukawa, Shu
Nakamura, Jun
Shinka, Toshiaki
Ogawa, Takatoshi
Mori, Katsushi
Ohkawa, Tadashi
Yoshida, Toshihiko
Sone, Masanori
Sangen, Hisayoshi
発行日: Jul-1983
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 29
号: 7
開始ページ: 837
終了ページ: 848
抄録: Two cases of Sipple's syndrome are reported. The first case, a 36-year-old woman, was admitted because of paroxysmal hypertensive crises, headache, palpitation and sweating. There was a thumb's head sized mass in the right lobe of the thyroid gland but no abdominal mass. Endocrine examination showed a conspicuous rise in serum calcitonin and in plasma and urinary catecholamine level. In addition, serum adrenocorticotropic hormone, prolactin and parathormone values were high. CT-scan could detect a right large suprarenal mass lesion, and additional selective left inferior phrenic arteriography revealed left small suprarenal vascular mass. Based on these data, a diagnosis of medullary carcinoma of the thyroid gland (MCT) and bilateral adrenal pheochromocytoma was made. Two months after bilateral adrenalectomy, total thyroidectomy was performed. Histologic examination showed pheochromocytoma and MCT in both lobes. The provocation test by gastrin revealed on elevated serum calcitonin level in one of her children. The second case, a 26-year-old female, was admitted with right large abdominal mass. She noticed her abdominal mass in the third trimester, but had never had a history of hypertension. A right large abdominal mass and hypertension were found in her postpartum course. Physical examination revealed a hard mass in the left lobe of the thyroid gland. Findings from the hormonal studies, e.g., serum calcitonin, plasma and urinary catecholamine values, suggested MCT and pheochromocytoma. An aortogram demonstrated a large mass that occupied the right suprarenal region and CT-scan detected several masses on the left side. On trans-abdominal exploration, bilateral pheochromocytomas were found and removed. Total thyroidectomy was performed at an interval of four weeks. The pathology reports confirmed bilateral pheochromocytoma and MCT in both lobes of the thyroid gland. 42 cases of Sipple's syndrome in Japan were reviewed and discussed.
URI: http://hdl.handle.net/2433/120199
出現コレクション:Vol.29 No.7

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