膀胱内注入療法に関する研究

Abstract

1)膀胱内注入療法を155例の膀胱腫瘍症例におこなった.2)治療注入療法は, 60%に有効性が示された.治療注入のみで腫瘍が消失した症例は1年以内に同所再発をおこす可能性が高く, さらに予防注入をおこなう必要がある.3)長期注入療法は, 短期注入療法に比し優れた再発抑制効果を示した.4)再発性膀胱腫瘍は, 注入療法で再発率の低下を認めた.5)膀胱鏡的に腫瘍が認められず, 細胞診のみ陽性を示した症例に注入療法を施行したところ, 8例中5例に細胞診の陰性化を認めた

Intravesical instillation therapy was performed in 155 cases of urinary bladder cancer. In 60% of the patients treated by therapeutic intravesical instillation, antitumor effects were observed. The patients who were given only the instillation therapy frequently had recurrence of the tumor in the same site within one year. Therefore, in such cases prophylactic instillation seems to be necessary. The preventive effect of intermittent instillation therapy given over a long period was superior to that of concentrated instillation therapy given during a short period. The rate of recurring bladder tumors decreased after instillation therapy. Eight cases that were cystoscopically nonvisual tumors but indicated positive cytology were treated by intravesical instillation therapy. In 5 of these cases cytology was negative after treatment.