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タイトル: | 泌尿器科領域におけるホルモン・高分子坦体複合体の研究 --特に前立腺癌治療への応用-- |
その他のタイトル: | Studies on hormone-polymer composites in urological field--their application in prostatic cancer therapy |
著者: | 山中, 英寿 |
著者名の別形: | Yamanaka, Hidetoshi |
キーワード: | Animals Artificial Organs Delayed-Action Preparations Estramustine/administration & dosage Gonadotropin-Releasing Hormone/administration & dosage Humans Male Polymers Prostatic Neoplasms/drug therapy Rabbits Rats Testis Testosterone/administration & dosage/metabolism |
発行日: | Dec-1983 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 29 |
号: | 12 |
開始ページ: | 1579 |
終了ページ: | 1586 |
抄録: | Our studies on the application of hormone-polymer composites in urological field are discussed in this review. We first studied the modes of in vivo and in vitro release of testosterone from vinyl polymer-testosterone composites prepared by radiation-induced polymerization. It was ascertained by our group that in vivo and in vitro release of testosterone from biodegradable copolypeptide -testosterone composites as well as vinyl polymer composites was well controlled. Using this system, we were successful in preparing a testicular prosthesis, which was made of vinyl polymer-testosterone composites and was ascertained to release testosterone constantly for a long period in the dose range of clinical usage. We also applied this sustained release drug delivery system to the method of administration of an LH x RH agonist, which was one of the best therapeutic drugs for androgen dependent prostatic cancer. Sustained release of the LH x RH agonist in the dose range of clinical usage over a period of several months from copolymer-LH x RH agonist composites was confirmed in both male rats and in prostatic cancer patients. Prostatic cancer cells contain a major secretion protein (alpha-protein or estramustine-binding protein) and estramustine has a high affinity for alpha-protein. Therefore, we examined the effect of an estramustine-microsphere containing anticancer drugs, namely, the missile therapy for prostatic cancer. The missile therapy should open the way to specific and selective chemotherapy for prostatic cancer. |
URI: | http://hdl.handle.net/2433/120314 |
PubMed ID: | 6375311 |
出現コレクション: | Vol.29 No.12 |
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