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Title: Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease.
Authors: Akitake, Reiko
Watanabe, Tomohiro  KAKEN_id
Zaima, Chikage
Uza, Norimitsu  kyouindb  KAKEN_id
Ida, Hiroshi
Tada, Shinsuke
Nishida, Naoshi
Chiba, Tsutomu  kyouindb  KAKEN_id
Author's alias: 渡邉, 智裕
Issue Date: Apr-2010
Publisher: BMJ Publishing Group Ltd & British Society of Gastroenterology
Journal title: Gut
Volume: 59
Issue: 4
Start page: 542
End page: 545
Abstract: We report a case of immunoglobulin G4 (IgG4)-related sclerosing disease involving the pancreas, liver and salivary glands. Massive infiltration of IgG4-expressing plasma cells was seen in the liver and submandibular lymph nodes. Interestingly, accumulation of IgG4-expressing plasma cells was also seen in the colon and terminal ileum. Peripheral blood mononuclear cells (PBMCs) isolated from this patient exhibited enhanced production of IgG4 and interleukin-10 upon stimulation with Toll-like receptor (TLR) ligands as compared with those from a healthy control. In contrast, production of tumour necrosis factor alpha and interferon gamma by PBMCs from this patient was markedly reduced. Since colonic mucosa is always exposed to TLR ligands derived from commensal organisms, the results of immunological studies suggest that enhanced T helper type 2 responses to intestinal microflora may underlie the immunopathogenesis in this patient with IgG4-related sclerosing disease.
Rights: © 2010 BMJ Publishing Group Ltd & British Society of Gastroenterology
DOI(Published Version): 10.1136/gut.2009.200972
PubMed ID: 20332525
Appears in Collections:Journal Articles

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