泌尿器科領域におけるCarbenicillinの使用経験

Abstract

Thirty-one cases of pyelonephritis were treated with carbenicillin (CB-Pc). Five were given 4 g×7 days, twenty-five given 4 g x 14 days and one 16 g×10days. Evaluation of the clinical response was made based on changes in fever, leukocytosis, pyuria and urinary bacteria. The results were as follows: excellent 11, good 10, fair 3 and non-effective 1. Six cases showed alteration of microbial flora. Thus, effective cases were counted as 21 with effectiveness rate 67.7 %. Of five cases from which urine Pseudomonas aeruginosa was isolated, one showed very good response and three good. Effectiveness rate in this group was therefore 80.0 %. No side effects were observed except for slight swelling and redness of i.m. injection site in two cases. Even in six cases with impaired renal function, further aggravation due to the drug was never noted. From the above findings, CB-Pc could be regarded as a useful antibiotic against urinary tract infection.