腎盂造影剤iothalamate(Conray)の糸球体濾過と点滴静注性腎盂撮影(DIP)

Abstract

Analytical studies of renogram and renal clearance study of [131]I-sodium iothalamate were carried out. The latter was measured by conventional procedures employing the urinary volume/plasma relationship as well as by a single injection and external counting method. It was confirmed that the urographic contrast medium, iothalamate, was excreted from kidney by glomerular filtration. Two hundred milliliters of 35 per cent solution of meglumin iothalamate (Conray) was infused into 206 patients, 218 times, and urographic quality obtained by this drip infusion pyelography was analyzed. The results were as follows: (1) Short-term fluid deprivation was of value for patients with adequate renal function. (2) Eighty per cent of patients with bilateral non-visualizing kidney and 86.3 per cent with unilateral on routine IVP were opacified by DIP. (3) Patients with renal insufficiency, over 1.5 mg/dl of serum creatinine level, obtained satisfactory pyelogram in 20/27 (74 %). (4) Because of the marked diuretic action and excellent opacification, DIP was valuable to evaluate the state of hydronephrosis. (5) The other clinical advantages were also confirmed. (6) No significant side reaction was observed in this series. Relationship between administration of large amounts of contrast medium and roentgenologic visualization of urinary tract was discussed from the standpoint of renal excretory function.