ラットの前立腺および精嚢におよぼすgestonorone caproateの影響

Abstract

The effect of long acting gestonorone caproate on the accessory sex glands and on the function, morphology and enzyme histochemistry of the testicle as well as on the libido of adult male rats were investigated. The Weight of the prostate and seminal vesicles following treatment for 6 and 15 weeks was reduced approximately 40-70 %, whereas the weight and the histological and histochemical appearance of the testicles remained unchanged as compared to the controls. An effect on the libido was not observed. A five-week treatment of hypophysectomized male rats supplemented with human chorionic gonadotropic hormone resulted in a reduction in weight of prostate and seminal vesicles of approximately 30 % compared to hypophysectomized control animals supplemented with human chorionic gonadotropic hormone. From these experiments, it is assumed that gestonorone caproate has a direct effect on prostate and seminal vesicles independent of the pituitary gland. The basic mechanism of this effect is unknown at present.