Double Blind法によるRifampicinの検討

Abstract

A double blind study was made on rifampicin (RFP) and cephaloglycin (CEG) for 55 nonspecific urinary tract infections. RFP was administered 900 mg/day (b. i. d.) and CEG 2 g/day (q. i. d.), each for three days. Of 42 acute cystitis, 23 were treated with RPF and a11 responded, whereas 19 were treated with CEG and 17 responded (Table 2). There was, however, no statistically significant difference between the effectiveness rate of both drugs (p=O.1988). Out of 13 cases of urinary tract infection other than acute cystitis, 6 were treated with RFP and 3 were cured while 7 with CEG and 4 cured (Table 3). MIC of RFP for the isolated organisms from the cases above mostly ranged between 6.25 and 25 mcg/ml (Table 5). Disappearance rate of urinary microorganism after drug administration for acute cystitis was 96 % CZZ/Z3) in RFP-group and 63 % (12/19) in CEG-group. This shows superiority of RFP (p=O.0098). Even after three days' administration, increased RFP-resistance was proved in 4 strains (Table 7). No side-effects were encountered.