Tiemonium Iodide(Visceralgine)の尿管運動に対する作用に関する臨床実験ならびにその使用成績

Abstract

Effect of tiemonium iodide (Visceralgine) on normal ureteral contractile activity was studied on 15 human subjects (25 ureters) by means of strain gauge manometer. The clinical effect, especially, of subsiding pain by this agent was also studied in 41 urological patients. For the former study, 5 mg (8 cases) or 10 mg (7 cases) of Visceralgine were administered intramuscularly. The following results were obtained. 1) In 3 cases (one with 5 mg; two with 10 mg), irregular spastic contraction of the ureter was released, resulting in normal pattern (Fig. 1, 4 and 5). 2) In 2 cases (both with 10 mg), spastic contractile waves became more regular than before. 3) In 2 cases (both with 10 mg), ureteral contraction stopped for several minutes after administration, followed by accelerated contractions, rather (Fig. 6 and 7). Efficacy rate of Visceralgine for urological use was found to be approximately 70 % in most of the reports. According to our study on 41 patients, the efficacy rate of this drug was 70.7%. Visceralgine was particularly effective for 62.5 % of vesico-urethral irritability. No side-effect was observed.