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タイトル: Carbenicillin(α-carboxybenzyl penicillin)に関する基礎的,臨床的検討
その他のタイトル: Laboratory and clinical evaluation on carbenicillin
著者: 桐山, 啻夫  KAKEN_name
酒徳, 治三郎  KAKEN_name
著者名の別形: Kiriyama, Tadao
Sakatoku, Jisaburo
キーワード: Adult
Aged
Ampicillin
Animals
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Penicillins/metabolism/pharmacology/therapeutic use
Rats
Urinary Tract Infections/drug therapy
発行日: Nov-1970
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 16
号: 11
開始ページ: 683
終了ページ: 687
抄録: The report deals with the laboratory and clinical assessment of Carbenicillin (CB-PC) on urinary tract infection. The results obtained were as follows. 1) The MIC of CB-PC against 268 strains of bacteria isolated from urinary tract infection were determined by plate dilution method. The MIC were less than 12.5 mcg/dl in 25% of Staphylococcus aureus, 66.1 % of Staphylococcus epidermidis, 26.7 % of Enterococcus, 5 % of Klebsiella, 38.1 % of E. coli, 37.5 % of Proteus vulgaris, 87.5 % of Proteus mirabilis, 66.7 % of Citrobacter, 14.3 % of Cloaca, 66.7% of Morganella, 50 % of Alcaligenes vulgaris and all of Providencia. The MIC of Pseudomonas aeruginosa ranged in 25 to 250 mcg/dl. As compared with AB-PC, CB-PC was more active against Klebsiella, Proteus vulgaris and Pseudomonas aeruginosa and less active against Staphylococcus. 2) Serum concentration following an intramuscular administration of 1.0 gm in three healthy adults reached the peak level of 20.8 mcg/ml in average after 30 minutes. Urinary recovery was 49 % and concentration was 1.227 mcg/ml for 6 hours. 3) Rat tissue assays were performed 30 minutes following an intramuscular injection of 20 mg per kg body weight and the kidney had the highest activity of 51.3 mcg/g in average of three rats. Other tissues were in the following order, liver, blood, lung and spleen. 4) Of 9 patients with secondary infection by Gram-negative rod after surgical procedures, six were treated effectively receiving parenterally 4.0 gm a day for 5 to 7 days.
URI: http://hdl.handle.net/2433/121189
PubMed ID: 5530621
出現コレクション:Vol.16 No.11

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