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Title: 2-acetylaminofluoreneによるラット膀胱腫瘍発生に対するβ-glucuromidase阻害剤の影響について
Other Titles: The effect of added dietary beta-glucuronidase inhibitor on the occurrence of 2-acetyl-aminofluorene induced bladder tumors in rats
Authors: 宮川, 美栄子  KAKEN_name
Author's alias: Miyakawa, Mieko
Keywords: Acetic Acids
Adipic Acids/pharmacology
Glucuronidase/antagonists & inhibitors
Time Factors
Urinary Bladder/drug effects
Urinary Bladder Neoplasms/chemically induced
Issue Date: Nov-1970
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 16
Issue: 11
Start page: 653
End page: 669
Abstract: The effect of 2, 5-di-O-acetyl-D-glucosaccharo-(l→4)(6→3)-dilactone (SLA:β-glucuronidase inhibitor) on tumorigenesis of 2-acetylaminofiuorene was experimentally studied by observation of the early changes in the rat vesical mucosa. 1) Hyperplastic index was compared in the various diet groups after 20 weeks of experimental feeding. a) Pyridoxine-deficient food group. Hyperplastic index was somewhat lower in the SLA-added group. b) Tryptophan-added group. There was no difference of hyperplastic index between the SLA-added and non-added group. 2) The bladder mucosa was studied by 3H-thymidine autoradiography and labeling index was calculated. Occurrence rate of the bladder tumor within 25 weeks was also compared. a) Pyridoxine-deficient food group. Significant difference was observed between the SLA-added and non-added group. This might be explained by Boyland's hypothesis. b) Tryptophan-added group. The effect of SLA was shown in labeling index but not in tumor occurrence rate. This suggests the presence of carcinogenesis not explained by Boyland's hypothesis and not inhibited by SLA.
PubMed ID: 5530618
Appears in Collections:Vol.16 No.11

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