膀胱腫瘍の再発に対するβ-glucuronidase阻害剤(SLA)の効果

Abstract

Thirty-one patients with pedunculated, non-infiltrative tumor of the bladder was continuously administered SLA, beta-glucuronidase inhibitor, after surgery. The recurrence rate of the SLA-treatment group was 12.9 % within six months, 38.1 % within one year, 50.0 % within two year, and 81.8 % within three year. This result was compared with the recurrence rate of the non-prevention group in the preceding paper. Within the first two years, the recurrence rate was always lower in the SLA-group though not so significantly by statistical analysis. Some cases obviously showed the preventive effect of SLA against recurrence of tumor of the bladder. One patient complained of anorexia and nausea due to SLA, which was discontinued after two months administration.