線維素溶解酵素系よりみたいわゆる特発性腎出血

Abstract

Fibrinolytic enzyme activity was studied in 15 patients with essential renal bleeding seen at the Department of Urology, Chiba University Hospital. Factors related with the fibrinolytic enzyme system were measured by the fibrin plate method on the blood samples taken from various sites such as both renal veins, aorta, antebrachial vein as well as on the split renal urines. The values obtained were statistically investigated. The control blood samples were obtained from 8 healthy persons. The substances in th e blood fibrinolytic enzyme system were in the non-activated state in the control group, whereas it was in the activated state in the patients. The large amount of tissue activator was observed to be rel e ased from the affected kidney into the general circulation. The total plasmin value of the venous blood from the non-affected kidney was lower than that of the aortic blood. As to urinary activator, even the urine s from the non-affected kidneys showed the higher values than the control urines. The urines from the affected kidneys showed much higher activator level. It was conjectured that the kidneys of so-called essential hematuria discharge both blood proactivator and activator into the urine.