Gentamicinの局所療法

Abstract

We tried the local infusion therapy with gentamicin t o 31 patients (total sites : 37) with urinary tract or surgical wound infection, which developed after urological operation and failed to respond to many other antibiotics. 1. The infusion can be divided into three groups as follows : 1) In 16 cases, gentamicin was infused into the renal pel v is through nephrostomy catheter or retragrade ureteral catheter (splint catheter). 2) In 8 cases, gentamicin was infused int o the bladder through suprapubic cystostomy catheter or transurethral indwelling catheter. 3) In 13 cases, gentamicin was infused d i rectly or through drain into the wound fistula. 2. Gentamicin injectable, original solution or solution diluted to 3 or 4 times with sterile distilled water, was infused into the locals 1 or 2 times daily for more than 3 days. 3. Before the treatment with gentamicin, microorganisms such as Proteus or Pseudomonas were isolated from urine or purulent discharge. The topical treatments with gent a micin were all successful except one case (pyelonephritis) which improved later on by intramuscular administration. Though there were some patients with renal or hepatic impairment before the treatment with gentamicin, no adverse reaction was observed for a course of gentamicin therapy.