皮膚転移および著明な多形性を示した腎腺癌

Abstract

This is a case report of rather unusual adenocarcinoma of the kidney seen in a 76-year, old woman. She showed metastases to the lung and skin. The left kidney was removed. There was remarkable pleomorphism microscopically. Anaplastic changes as well as osseous and cartilaginous metaplasia were conspicuous. The tumor was mostly composed of highly malignant undifferentiated cells of epithelial origin and small areas were populated by differentiated clear cells as usually seen in the typical Grawitz' tumor. The unfavorable clinical course of this patient might be related with the above histological findings. It was stressed in this paper that pleomorphism or anaplastic changes might be one of the factors as to prognosis of renal adenocarcinoma. In addition, review of literature was made on skin metastasis of renal adenocarcinoma.