雄性性腺系の亜鉛にかんする実験的および臨床的研究

Abstract

The zinc concentration in the male genital organs of rats, dogs and men has been measured by means of atomic absorption spectrophotometry. The influence of antiandrogenic hormones to the zinc concentration in the organs was also studied. The results obtained are as follows; 1. As to the zinc concentration in the male genital organs of rats, the dorsolateral prostate showed the highest mean value of 49.1 mcg/g wet weight, while cauda epididymis, caput epididymis, testis, coagulating gland, ventral prostate and seminal vesicle averaged 27.3, 27.0, 21. 2, 19.7, 15.3 and 12.9 mcg/ g wet weight respectively. As for the total zinc contents of a pair of organs, the study was performed on a unilateral organ. The testis revealed the highest mean value of 26.2meg/organ, while dorsolateral prostate, seminal vesicle, ventral prostate and coagulating gland averaged 6.6, 2.3, 1.3 and 0.9mcg/organ respectively. As for the total zinc contents of a pair of organs, the study was performed on a unilateral organ. The testis revealed the highest mean value of 26.2meg/organ, while dorsolateral prostate, seminal vesicle, ventral prostate and coagulating gland averaged 6.6, 2.3, 1.3 and 0.9mcg/organ respectively. 2. With regard to the zinc concentration in the male genital organs of dogs, the prostate showed the highest mean value of 133.4 mcg/ g wet weight, although, cauda epididymis, caput epididymis and testis averaged 19.0, 16.6 and 10.3 mcg/ g wet weight. 3. The influence of the three kinds of antiandrogenic hormones, diethyl•dihydroxystilbenediphosphate (Honvan), 17-α-hydroxy-19-norprogesterone caproate (SH 582) and estradiol valerianate (Proginon depot) to the zinc concentration in the male genital organs of the rats was evaluated. The concentration decreased significantly in the dorsolateral prostate with the administration of Bonvan in the dorsolateral prostate and the testis with SB 582 and the testis with Proginon depot compared with those of the normal controls. The significant decrease of total zinc contents of the organs was recognized in the testis and in the dorsolateral prostate in all the treated• groups, as well as in almost all the other organs of the groups. 4. Likewise, the influence of the three hormones to the zinc concentration in the male genital organs of the dogs was estimated. The concentration declined significantly in the prostate, in the testis and in the epididymis with the administration of Bonvan and SB 582. The prominent decline of the concentration in those given Proginon depot was initially found in the prostate, then in the testis, and finally in the epididymis as the dose of the hormone was increased. 5. In relation to the zinc concentration in the genital organs of the men examined, the prostates which were postmortem specimens, marked the highest mean value of 33.6 mcg/ g wet weight. The cadavers were treated with formalin and red lead before preservation. The concentrations in the other organs which were surgically extracted from the patients of prostatic carcinoma, caput epididymis, cauda epididymis and testis averaged 16.4, 15.7 and 10.6 mcg/g wet weight respectively. 6. Furthermore, the influence of the therapeutic dose of Honvan and SH 582 to the zinc concentration in both the testis and the epididymis of the patients of prostatic carcinoma was examined. The concentration showed a decreasing tendency, however, no statistically significant difference was proved compared with those of the normal controls. The significant decrease of the total zinc contents of the testis treated with Honvan was confirmed. 7. The zinc concentration in fertile human seminal plasma averaged 204.5 mcg/ g wet weight. A study was performed in connection with sperm count in sterile patients, though only a group of azoospermia averaged the concentration of 120.2 mcg/ g wet weight, which denoted a statistically significant decrease compared with the normal controls. In a similar study relating to sperm motility, only a group of necrozoospermia showed the average of the concentration of 78.3 mcg/ g wet weight. The result pointed out a prominent decrease, but not a statistically significant decrease, compared with the normal controls. The zinc concentration in fertile human seminal sediment averaged 266.3 mcg/ g wet weight. No significant relation was found between zinc concentration of sterile seminal sediment and sperm count or motility. Moreover, the concentration in sterile seminal sediment proved no statistical difference from that of the normal controls. 8. The zinc concentration in sterile human seminal plasma seemed to increase in proportion to the increase of total urinary gonadotropin. No statistical analysis was performed because of the small number of cases.