乏精子症および無精子症の血中FSHとLH

Abstract

Plasma FSH and LI-I were determined by radioimmunoassay on six normozoospermic men, twelve oligozoospennic (sperm concentration less than 40×10[6]/ml) and thirty-four azoospermic. Klinefeter's syndrome and obstructive azoospermia were excluded from this study. Plasma FSH of the azoospermic group (18.1mIU/ml) was sigificantly higher than that of the normozo-oligozoospermic group (11.1mIU /ml). Azoospermic men having no germ cells on testicular biopsy showed plasma FSH as high as 21.0 mIU/ml. Those having germ cells, however, showed no significant increase of FSH compared with the normozo-oligozoospennic group. There was no correlation between testicular biopsy score count and plasma FSH. Plasma LH of the azoospermic men without germ cells on testicular histology was 27.6 mIU/ml which was significantly higher than that of the normozo-oligozoospermic group (18.2mIU/ml). Plasma LH of the azoospermic men without germ cells showed positive correlation with their plasma FSH. From the above results, it might be suggested that FSH inhibiting factor originating from the germ cells probably gives suppression on production of FSH whereas androgen on release of FSH.