膀胱内注入抗菌性物質の膀胱壁内移行

Abstract

"Neomyson G Injection", containing thiamphenicol aminoacetate hydrochloride, was intravenously given to male adult dogs, and the concentration of thiamphenicol diffused into the bladder tissue as well as its urinary and serum concentrations were determined. It was demonstrated that a major part of the concentration in the bladder tissue came from the blood, while the rest considerable part from the urine. The diffusion rate of thiamphenicol from the urine into the inflammatory bladder tissue was more significantly higher than that into the normal. It was, therefore, suggested that such a drug as maintaining its higher urinary concentration would be more effective in the chemotherapy of urinary tract infection, especially of cystitis.