尿路感染症に対する抗生物質の尿中濃度の意義に関する実験的研究

Abstract

An experimental study was made using dogs with cutaneous ureterostomy in order to elucidate the significance of concentration in urine of an antibiotic for urinary tract infection. The antibiotic chosen was cephaloridine (CER). 1. It was proved that CER in the vesical urine was mostly of renal origin and partly of vesical tissue origin. 2. Concentration of CER in the vesical tissue was higher in the intact dogs than in the dogs with ureterostomy. This suggests that the antibiotic in the bladder tissue originates from the blood as well as from the urine in the bladder. 3. Implantation of the cellulose tube containing E. coli was made both on the control dogs and dogs with ureterostomy. In the former group, pretty high concentration of CER was proved in the tube in 4 hours resulting in disappearance of the microorganism. In the latter group, however, microorganism decreased but persisted. 4. Experimental cystitis was made both in the control dogs and dogs with ureterostomy, and CER was administered intravenously. The microorganism in the inflammatory vesical tissue was followed by means of bioautography. Inhibition of the growth was observed in 12 hours in the former group but not in the latter group even at 48 hours. From the above results, concentration of the antibiotics in urine is of great importance, therefore, an antibiotic of choice should be such as one having high urinary excretion rate. On the other hand, the antibiotic in the vesica1 tissue cannot be ignored because the site of inflammation is tissue itself.