阻血性腎障害に対するウレタン誘導体およびATPの効果に関する実験的研究

Abstract

Present author studied the effect of urethane derivatives (UD) and ATP on the renal ischemic damage resulting from temporary occulsion of renal vessel during palliative operation of the kidney. Unilateral nephrectomised male dogs were used. Renal blood flow was interrupted for 100 minutes. Fifteen minutes before interruption, butylmorpholine urethane was administered at rate of 50 mg/kg b. w. and postoperatively ATP was administered intravenously at rate of 100 mg/day. Biological, histochemical, and histological examinations were made. Two groups, one nontreated and another administered ATP, demonstrated severe ischemic renal damage and mostly died. The other two groups, one given UD and another UD with ATP, were alive at 14th days postoperatively. The group, which was given UD, demonstrated not only severe ischemic renal damage at the 4th postoperative day, but mild elevation of BUN as well as biological and histological mild renal damage at the 14th postoperative day. On the other hand, the group, which was given UD with ATP, indicated mild ischemic renal damage at 4th day and returned to normal at the 14th postoperative day. This result indicate that UD with ATP administration was more effective than administration of only UD.