前立腺肥大症に対する黄体ホルモン剤療法の検討

Abstract

Forty-one patients with benign prostatic hypertryophy where prostatectomy was not indicated from some reasons were treated with gestonorone caproate, a progestational agent. As the scheduled program it was administered intramuscularly 300 mg once a week for ten weeks, but, if necessary, it was continued for a longer period. At the end of the treatment somehow beneficial effects were clinically verified in 32 cases (78.0 %) of them. A follow-up study was made as to ascertain long-term results after the treatment. The results revealed that, of 28 cases pursued, 23 cases (82.2 %) reported to have satisfactory conditions of micturition. Characteristic findings by electron microscopic examination of the prostatic tissue after the treatment with gestonorone caproate were markedly enlarged intercellular spaces between adjacent epithelial cells and an abundance of fibroblasts and collagenous fibers in the stroma. Treatment with gestonorone caproate may be recommended in some cases of benign prostatic hypertrophy, where prostatectomy could not be indicated from some reasons, because of the verified clinical effects and absence of any significant side-effect.