遊走腎症の保存療法 - とくに cyproheptadine を使用した場合 -

Abstract

(1) 21 cases out of 27 nephroptotic patients (female 16, male 5), that had no urinary tract infection or no renal function disturbances, were treated conservatively by the daily oral administration of cyproheptadine (24 mg/day) and the intermittent oral administration of Methylandrostenolon onanthat (100 mg/every 2 weeks) with the simultaneous use of Elegance Band (KANEBO). (2) Cyproheptadine is supposed to have the stimulating effect for the lateral part of the hypothalamus and also the inhibiting effect for the ventromedial nucleus, so it clinically results in some inprovement of the appetite and weight gain. Methylandrostenolon 6nanthat was used as one of the anabolic steroids. (3) By the use of these drugs during 35 days to 98 days, 71.4% of the 21 cases showed to have improved in the appetite and gained 5.7 kg in weight on an average. Also those slight complaints like flank dullness, stiff sholders, bladder irritability, macrohematuria, and proteinuria, were relieved completely in 58.4% and partially in 29.2% of the all 24 ones. 13 cases out of the 16 females (81.3%), who had worn the Elegance Band, became unnecessary of it. (4) IVP revealed that the ptotic range of the nephrogram was within 2.2 cm long. (5) In 4 cases drowsiness and malaise were recognized as the side effects, and in 2 cases of these the administration of the drugs was discontinued on the 18th and 28th day respectively.