The Histological Changes in the Liver and in the Urinary Bladder In Mice fed Benzidine whose Bladders Contained Glass Beads

Abstract

Administration of benzidine followed by the implantation of a glass bead into the lumen of the bladder did not lead to tumor of the urinary bladder. There was no bladder tumor induction in mice given the chemical alone or in mice implanted with a glass bead alone. Hepatoma was observed in 19 out of 68 animals fed benzidine. Benzidine seems to be hepatocarcinogenic to female d, d strain mice but not carcinogenic to the bladder even under the above condition.