Panfuran-Sの急性膀胱炎に対する二重盲検法による臨床的評価

Abstract

The clinical effects of Panfuran-S (test drug abbreviated as FT) on acute simple cystitis were studied by the double blind method with cephalexin (CEX) as the control drug. The total number of subjects was 107 cases, of which 81 cases could by evaluated about the effects on the 4th day, 74th cases on the 7th day. In the separate evaluation of subjective symptoms, leukocytes in urine and bacteria in urine (microscopy) on the 4th and 7th day, there was no significant difference between the FT and the CEX group. Clinical effects totally evaluated according to the criteria on subjective symptoms, leukocytes in urine and bacteria in urine on the 4th and 7th day showed no significant difference between the FT and the CEX group. The efficacy rates of FT on 4th and 7th day were 70.096 and 71.8%, and that of CEX were 85.0% and 91.4% respectively. Most of clinically isolated strains were E. coli. In the relation of clinical effects to the disc sensitivity to E. coli on the 4th day, no significant difference was observed between the FT and the CEX group. Side effects (gastrointestinal disorders) were observed in 26% of the FT and in 14% of the CEX group, but according to hematological and blood chemistry findings before and after administration of FT and CEX, no disorders caused by drugs were observed.