ヒト前立腺肥大症組織とRobaveron 2.前立腺肥大組織のTestosterone代謝におよぼすRobaveronの影響

Abstract

In order to investigate the effect of Robaveron on prostate, the prostatic tissues surgically removed were incubated with testosterone-4-14C, and then by subcellular fraction of the cultured prostatic tissues, the testosterone metabolites were analyzed. 1) Dihydrotestosterone (DHT), 5a-androstanediol, 5a-androstenedione and , ⊿4-androstene dione were identified as metabolites of testosterone. DHT was most identified. 2) Testosterone metabolism was a little suppressed with Robaveron. In the supernatant of the tissues, the 5a-reduced products were increased. On the contrary, in the nucleic fraction, these were not so much promoted. 3) In view of the production of DHT, it was thought that Robaveron accelerated 5α-reductase activities in cytoplasm, and the conjugation of receptor protein with DHT was retarded. Consequently, it was assumed that Robaveron had a kind of anti-androgenic action.