ヒト前立腺肥大症組織とRobaveron 1.Robaveron加組織培養における前立腺組織の変化

Abstract

The prostatic hypertrophic tissues which were surgically extirpated, were cultured with Eagle's MEM medium containing insulin and testosterone. In order to investigate the direct effect of Robaveron on prostatic tissue, Robaveron in various concentrations were added to the culture medium, and then the effects were examined histologically. Acid phosphatase activity of the cultured prostatic tissues was most prevented by Robaveron in the concentrations of 1.6×10[-1] to 1.6×10[-2] mg/ml. On the contrary, alkaline phosphatase activity didn't show any particular influence. Incidentally, morphological changes were observed in the cultured prostatic tissues, when Robaveron in the same concentration was added, that glandular epithelium was flattened out and fell off, and also that acinar folding was decreased. Consequently, it was concluded that Robaveron might have direct effect on prostatic tissue, and also that the result would coincide with clinical results.