前立腺肥大症に対するEviprostatの臨床効果について (二重盲検法)

Abstract

Clinical effect of Eviprostat was investigated by a double-blind study on 111 patients with prostatic hypertrophy mainly of initial stage and partly of obstructive stage inadequate for operative treatment due to various complications. The following results were obtained. 1) Evaluation of total effect using analogue scale proved that Eviprostat was significantly superior to the placebo. 2) Therapeutic effect consisted of improvement of various symptoms and signs such as residual urine feeling, frequent urination, retardation, protraction, abdominal pressure needed on urination and small stream. However, residual urine volume and urine flow rate did not change significantly. 3) As to side effects, anorexia and pruritus was seen in one case respectively in the Eviprostat group (68 patients), whereas anorexia in one case in the placebo group (69 patients). These did not necessitate discontinuation of the drugs in both groups.