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Title: PT-122Mの腎機能障害時における血中濃度の推移と血液生化学値に及ぼす影響
Other Titles: STUDIES ON PT122M : PLASMA CONCENTRATION IN IMPAIRED RENAL FUNCTION AND EFFECTS ON BLOOD CHEMICAL VALUES
Authors: 加藤, 廣海  KAKEN_name
袴田, 隆義  KAKEN_name
浜野, 耕一郎  KAKEN_name
堀内, 英輔  KAKEN_name
多田, 茂  KAKEN_name
Author's alias: Kato, Hiromi
Hakamada, Takayohi
Hamano, Kohichiroh
Horiuchi, Eisuke
Tada, Shigeru
Issue Date: Oct-1975
Publisher: 京都大学医学部泌尿器科学教室
Journal title: 泌尿器科紀要
Volume: 21
Issue: 9
Start page: 877
End page: 891
Abstract: PT-122M (doxycycline hydrochloride) was administered intravenously to 4 subjects with normal renal function and 7 with moderately impaired and 11 with severely impaired. Plasma concentration and urinary excretion of the given antibiotic were investigated. Dosage was 200 mg on the first day and 100 mg per day for the following six days. No accumulation of the drug was observed in those who have some renal function left. Some accumulation was noted in those under hemodialysis because of no renal function. Blood chemical data remained stable despite administration of the drug. Only one case complained nausea which was relieved by slowing the speed of intravenous injection. No side effects were observed in others.
URI: http://hdl.handle.net/2433/121874
Appears in Collections:Vol.21 No.9

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