|Title:||ウレアーゼ阻害剤による尿路結石の予防 第1報: 感染尿とウレアーゼ阻害剤|
|Other Titles:||PREVENTION OF INFECTED URINARY STONES BY UREASE INHIBITOR 1.INFECTED URINE AND UREASE INHIBITOR|
|Authors:||竹内, 秀雄 |
|Author's alias:||Takeuchi, Hideo|
|Abstract:||In vitro effect of nicotinohydroxamic acid in lowering urine pH was investigated. 1) Nicotinohydroxamic acid markedly inhibited elevation of urine pH and crystallization of phosphate. 2) No anti-microbial effect was proved if concentration of hydroxamic acid is lower than 0.70 mg/ml. 3) Urine alkalinization was noted only in Proteus group, but not in either of Pseudomonas, Klebsiella or E. coli group. 4) Precipitation of salt on the balloon cathters was inhibited by nicotinohydroxamic acid. 5) A great possibility was suggested from the study that hydroxamic acid might be a powerful medicine in preventing the phosphate calculi.|
|Appears in Collections:||Vol.22 No.2|
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