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Title: 腎細胞癌にみられる肝機能障害
Other Titles: HEPATIC DYSFUNCTION ASSOCIATED WITH RENAL CELL CARCINOMA
Authors: 増田, 富士男  KAKEN_name
佐々木, 忠正  KAKEN_name
渡辺, 秀雄  KAKEN_name
荒井, 由和  KAKEN_name
町田, 豊平  KAKEN_name
Author's alias: Masuda, Fujio
Sasaki, Tadamasa
Watanabe, Hideo
Arai, Yoshikazu
Machida, Toyohei
Issue Date: Feb-1976
Publisher: 京都大学医学部泌尿器科学教室
Journal title: 泌尿器科紀要
Volume: 22
Issue: 2
Start page: 91
End page: 96
Abstract: Liver function of the patients with renal cell carcinoma was investigated on 65 cases experienced during Jan. 1963 to March 1975. Liver function was estimated by serum alkaline phosphatase, GOT, GPT, gamma-GTP, bilirubin, prothrombin time and α2-globulin. Liver function was considered to be impaired whenever three of above parameters showed abnormal value. Six of 65 (9.2%) had impaired liver function. In none of them metastasis to the liver was found at the time of surgery. Hematuria was noted in three of six, pain in three, mass in five, pyrexia in five and varicocele in three. High percentage of varicocele may suggest that the cause of liver dysfunction might be tumor invasion from the renal vein to the van a cava or compression over the vena cava or hepatic circulation by tumor. Removed kidneys of six cases weighed 420 to 1000 g (average 690 g), being relatively larger than usual. Histologically, 5 was clear cell type, and one was mixed cell type. Biopsy study of the liver was made in two cases. One showed marked fatty degeneration, and another moderate fatty degeneration, hepatocellular necrosis and cellular infiltration. Three cases who are alive showed the return to the normal liver function after nephrectomy. Impaired liver function without liver metastasis should be paid urologist's attention for early diagnosis of renal cell carcinoma. Impaired liver function does not mean the contraindication of nephrectomy. Postoperative change of liver function may tell the prognosis well.
URI: http://hdl.handle.net/2433/121928
Appears in Collections:Vol.22 No.2

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