Carfecillinの尿路感染症に対する臨床的検討

Abstract

Carfecillin was administered for urinary infection seen in the patients having indwelling catheter or renal stones, 11 caused by Pseudomonas aeruginosa and 3 by Proteus species. The total dosage was 56 grams for 14 days. Elimination of pathogens, improvement of urinary findings and subsidence of subjective symptoms were obtained in 54.5% of the cases infected by Pseudomonas aeruginosa, and in 33.3% of the cases infected by Proteus species. Mild gastrointestinal symptoms occurred in 21.4% of the cases. In vitro antibacterial activity of CBPC against 16 strains of Pseudomonas aeruginosa isolated from the urine of patients was inferior to that of minocycline. But, under usual dosage, urinary excretion of CBPC is higher than that of minocycline, and Carfecillin appeared to be more advantageous for the case of Pseudomonas urinary tract infection than minocycline. Against Proteus mirabilis, antibacterial activity of CBPC was more sensitive than that of minocycline. Against another Proteus species, CBPC was inferior to minocycline except Proteus morganii.