シンチカメラによる腎機能検査法に関する臨床的研究(第1報) - 99mTc-DMSA腎シンチグラフィ -

Abstract

Conventional renal cortical imaging agent, 203Hg chlormerodrin, has become replaced by 99mTc tagged agents, because of its high radiation hazard to attain high quality imaging especially by scintillation camera. Among these reported agents with 9gmTc labeling, a new radiopharmaceutical, 90mTc-dimercaptosuccinic acid (DMSA), was evaluated for its validity of renal cortical visualization. Primaily, ten subjects with normal renal function were selected for kinetic studies. The initial distribution was mainly seen in the plasma compartment with negligible quantities of the label on red blood cells. Plasma clearance as well as urine accumulation data indicated that more than 50% of the administered dose was retained in the kidney, at least, during the present observation until 24 hours. These characteristics with higher affinity for renal cortex than these of other reported agents appear to be well suited for renal cortical imaging. By reviewing clinical studies of more than hundred cases, excellent cortical imaging was proved to be useful for the regional characterization of renal cortex and, further, to facilitate the definite delineation of cortical abnormalities even in an equivocal case who underwent the pyelography and/or selective renal angiography.