前立腺肥大症における前立腺切除術に伴う出血に対するtranexamic acid(t-AMCHA)の効果 -2重盲検法による比較試験-

Abstract

Tranexamic acid was administered to control hemorrhage during and following prostatectomy in prostatic hypertrophy, and its clinical effect was comparatively investigated with 10% saline as a control drug by means of a double blind method. The follwoing results were obtained. 1. Tranexamic acid was administered to 39 cases and placebo to 37 cases. No significant difference was noted between the two groups in various background factors. 2. The evaluation of clinical effect of each 'drug was decided according to the individual evaluation of the hemostatic effect on blood loss and abnormal bleeding (oozing) during operation and severity of postoperative hematuria. 3. The results were analyzed statiscally and significant difference was observed between these evaluations. Tranexamic acid group showed a highly significant reduction in bleeding during and following prostatectomy. The final clinical effect of tranexamic acid was excellent 51.3%, good 30.8% and poor 17.9%, while the effect of placebo was excellent 37.8%, good 10.8% and poor 51.4%. 4. As the side effect, only one case of tranexamic acid group showed slight nausea. 5. With the results obtained above, it was confirmed that tranexamic acid has marked hemostatic effect to control hemorrhage during and following prostatectomy in prostatic hypertrophy.