慢性前立腺炎治療における臨床症状の推移について - 消炎剤の二重盲検法による薬効の検討 -

Abstract

Chronic prostatitis is possibly the most common infectious disease in middle-aged men and is bacteriologically, pathologically studied by many clinical investigators. However, this still remains as one of the most troublesome diseases in outpatient clinics of urology. Then we reanalyzed the clinical features of chronic prostatitis during the treatment from the new standing points and evaluated the efficacy of antibiotics and anti-inflammatory agents in patients with chronic prostatitis. The whole 60 patients were administered AB-PC (1.5 g/day), and had the prostatic massage once a week for four weeks. Furthermore, nonsteroidal anti-inflammatory agents (Flurbiprofen 120mg/day) or its placebos were administered to all cases arranged by the double blind method. The results were as follows. 1. The therapeutic effect of anti-inflammatory agents was not so statistically significant. However the cases, having the remarkable subjective symptoms even after the four weeks treatment, were very few in the group treated with anti-inflammatory agents than in the group given placebo. 2. The effect of ordinary treatment (daily administration of AB-PC and prostatic massage once a week) were as follows. 1) The subjective syndromes improved to some extent (70%) in the first two weeks treatment. And remaining subjective symptoms showed relatively resistances to the treatment during the second two weeks period. The findings of expressed prostatic fluid were also improved in 54% during the first two weeks treatment, and in the second two weeks treatment they showed the minimal improvement. 2) The incidence of terminal discomfort or pain on urination was not so high, but these symptoms were apt to be non-reactive for treatment. On the other hand, the referred pain, residual urine sensation, pollakisuria that observed in high incidence were relatively reactive for treatment.