女子急性膀胱炎に関する化学療法剤に併用する塩化リゾチームの量的変化が治療効果におよぼす影響について

Abstract

Lysozyme is mucopolysaccharidase present in vivo, and has bacteriolytic, antibacterial and anti-inflammatory activities. Lysozyme was used in the chemotherapy of female acute cystitis and the effect of its quantitative variation on the therapeutic result was discussed. The subjects were 79 women with acute cystitis who came to the Urological Clinic of Kinki University Hospital and aged from 17 to 80 years. The control group including 20 patients were given only chemotherapeutics, the group consisting of 20 patients were given 100 mg lysozyme chloride (Neuzym@) per day together with the chemotherapeutics, the 200 mg group included 19 patients, and the 300 mg group contained 20 patients. The chemotherapeutic agents such as CEX, NA, AB-Pc were given with almost the same ratio. The therapeutic results were not so different between the 100 mg group and the control group. Though the ratio of the excellent effect was significantly higher in the 200 mg group than in the control group, the degree of the entire clinical effect in this group was not significantly different from that in the control group. In the 300 mg group, the ratio of the excellent result and the entire clinical effect were greatly superior to those in the control group. Accordingly, for obtaining the synergism of lysozyme chloride with chemotherapeutic drugs, administration of 300 mg/day is recommended.