表在性膀胱腫瘍に対するMitomycin CとCytosine Arabinosideの併用注入療法

Abstract

Intravesical combination chemotherapies of 20 mg of mitomycin C and 200 mg of cytosine arabinoside were performed in the sixteen patients with superficial bladder tumors. The clinical effects of these treatments were compared with the results of 6 cases with 400 mg of cytosine arabinoside alone (group 1), 27 cases with 20 mg of mitomycin C alone (group 2) and 20 cases with daily double trials of each of 20 mg of mitomycin C (group 3). The results were as follows. 1) Complete disappearances of tumors after a series of twenty times of these combination chemotherapies were found in 5 cases (31.3%), and the clinical effectiveness, complete disappearances and significant reductions of tumors, were found in 11 cases (68.7%). The clinical result of these combination chemotherapies was better than group 1 (33.3%) and group 2 (40.7%), and was as good as group 3 (80.0%). 2) No serious side-actions with the combination therapies were found. 3) We thought that the clinical effects on the bladder tumors were increased with these intravesical combination chemotherapies.