神経因性膀胱の排尿効率改善に対するロバベロンの効果についての研究

Abstract

Improvement of voiding efficiency with Robaveron was studied on 187 patients suffering from neurogenic bladder. Robaveron was administered intramuscularly for 3 weeks every day. Clinical efficiency with Robaveron was observed obviously taking the form of decrease in residual urine, obligatory ratio of residual urine and increase in bladder contractile activity. The results were discussed on three groups of neurogenic bladder; the upper motor neuron lesion type, the lower motor neuron lesion type and the patients after operation of uterine cancer. Decrease of residual urine was obtained by Robaveron in 19.6% (25.5ml), 37.0% (43.0ml) and 63.1 % (71.9ml) respectively. As to obligatory ratio of residual urine, it decreased 11.5%, 16.4% and 22.3% respectively. And as to the pressure amplitude (the difference between maximum voiding pressure and maximum resting pressure), it increased 28.3% (8.4 mmHg), 21.0% (10.4 mmHg) and 48.7% (12.7 mmHg) respectively. It was revealed by the cystometric study as well as urofiowmetric study that clinical effect of Robaveron was brought by the increase in active dynamics of detrusor muscle of urinary bladder. This clinical study showed that Robaveron is a reliable agent for improvement of voiding efficiency in neurogenic bladder, without any severe side effect including laboratory studies.