In vivoの血液濾過過程における血液中の各種成分の除去量をin vitroのそれから予測する方法

Abstract

An experiment was carried out in order to prove the hypothesis that k values which represent the ultrafiltration characteristics of the membrane are independent of the hematocrit value if less than 40% and do not differ greatly between the in vitro and vivo system. The ratio of concentration of a certain chemical component of the filtrate to that of the blood (φ) was shown to have nearly the same value except for urea nitrogen both in the in vitro and in vivo systems when blood flow rate was similar and the ultrafiltration membrane employed was the same in quality in both systems. Therefore, the ultrafiltration rate of the membrane in vivo for a certain blood chemical component except for urea nitrogen could be estimated from the corresponding data in vitro based on the theory advocated here whenever the concentration of any blood chemical component in blood was known.