膀胱癌患者の細胞性免疫能に関する研究 -第2報 : 末梢血リンパ球のsubpopulationについて-

Abstract

A nonspecific cellular immunity was measured by PHA induced blastogenesis of lymphocytes in the patients having bladder carcinoma. Peripheral lymphocytes counts of the patients was almost same as the age matched tumor-free patients. However, blastogenesis of lymphocytes with autologous serum was depressed as compared with age matched tumor-free patients. There was a significant converse correlation in lymphocytes blastogenesis to the grade and the stage of the tumor. Thus, two considerable factors: cellular and humoral factors were suggested to inhibit blastogenesis of lymphocytes in the patients with bladder caricnoma. Regarding cellular factor, a study was made on lymphocytes subpopulation of 23 patients with bladder carcinoma and of age11 matched tumor-free patients. Identification of lymphocytes was performed by means of rosette formation with sheep erythrocytes. T-cell was identified by spontaneous rosette formation with sheep erythrocytes (E-rosette), and B-cell was identified by EACrosette formation. There was a tendency of decrease in percentage and absolute count of T-cell in the patients with higher grade and stage of the tumor. Contrary, percentage of B-cell in the patients with tumor was significantly higher than that of tumor-free patients. However, percentage of B-cell was not correlated to the grade and stage of the tumor.