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Title: Flavoxate hydrochlorideのラット膀胱におよぼす効果:経口投与による効果について
Other Titles: EFFECT OF FLAVOXATE HYDROCHLORIDE ON BLADDER FUNCTION OF THE RATS: EFFECT OF PERORAL ADMINISTRATION
Authors: 加世田, 正和  KAKEN_name
佐藤, 昭夫  KAKEN_name
佐藤, 優子  KAKEN_name
照井, 直人  KAKEN_name
鳥潟, 裕子  KAKEN_name
Author's alias: Kaseda, Masakazu
Sato, Akio
Sato, Yuko
Terui, Naohito
Torigata, Yuko
Issue Date: Aug-1977
Publisher: 京都大学医学部泌尿器科学教室
Journal title: 泌尿器科紀要
Volume: 23
Issue: 6
Start page: 623
End page: 627
Abstract: Continuous cystometric recording through a balloon catheter was carried out on rat and changes after administration of AK-123 (f1avoxate hydrochloride) were studied. 1) Intragastric administration of AK-123 less than 62.5mg/kg showed no effect on the voiding contraction of the bladder. 2) Intragastric administration of AK-123, 125 to 250mg/kg, exerted inhibition on the voiding contraction starting 45 minutes and reaching the maximum level 60 to 75 minutes after the administration. The vesical contraction returned to the original level in 120 to 180 minutes. 3) Intragastric administration of AK-123 more than 500 mg/kg inhibited the vesical contraction and lowered the blood pressure remarkably. Both the veisical function and blood pressure did not return to the original level and the experimental animals got deteriorated.
URI: http://hdl.handle.net/2433/122113
Appears in Collections:Vol.23 No.6

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