膀胱腫瘍に対するcarboquoneの膀胱内注入療法 - 組織学的ならびに電子顕微鏡的検討 -

Abstract

Seven patients were treated by instillation of carboquone (CQ) into the bladder. Ten milligrams of CQ dissolved in 50 ml of sterile water were administered twice a week to the total amount of 100mg of CQ. The curative effect of CQ was evaluated by cystoscopy, pathology and electron microscopy. CQ was estimated to be excellent when the tumor completely disappeared. When the size of the tumor reduced, it was judged as moderately effective, and when no shrinkage or increase in size was observed, it was regarded as non-effective. In the clinical evaluation according to above criteria, it was summarized that excellently effective in 2 cases, moderately effective in 3 cases, and non-effective in I case. Frequent urination was oberved as a side effect only in one patient. In the pathological observations, one case changed into necrotic tissues and the tumor cells of 3 cases were shed off or degenerated following the administration of CQ. Concerning the electron microscopic observations, the tumor cell nucleus turned to have the smooth outline without any pseudonuclear inclusions or nuclear bodies, and the number of lysosomes within the cytoplasm decreased following the CQ treatment.